“You say, okay, of all the chemicals that I could make given my geometry, I don't want to make that many… you basically set up and generate a bunch of synthetic libraries and then you score them on this optimization function”

“We had a 100 million compound library that didn't help as much as better characterizing a smaller one… you can either spend more on sequencing a smaller set or get more molecules and hope noise averages out”

“Building trusting relationships cross-functionally… is the single skill that compounds the most over a career.”

“The subset that you're generating along the way is not itself intrinsically valuable… there are going to be a little bits of gold that we have generated as a consequence of doing all of the screening”

“…reward hacking… you just don’t see at smaller scales… it’s a step function… Kimi K3 is very good at coding and exhibits reward hacking.”