“We had this growing collection of activity cliffs and profiles of the same chemical material across large numbers of proteins”
IQ
Ian Quigley Leash Bio
Latent Space: The AI Engineer Podcast ·
“We buy a known binder, run the screen again… all the chemicals that normally go in the pocket will be displaced… then we mutate the pocket and see those series drop out.”
Ian Quigley · Latent Space: The AI Engineer Podcast · Lab-in-the-Loop at Compute Speed - Ian Quigley, Leash Bio
Play from 1:04:12
1:04:12
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What was described
Create negative training examples by mutating a protein pocket and running a competitive assay with a known binder to see which chemical series disappear
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Ian Quigley
Latent Space: The AI Engineer Podcast ·
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