“We take the DNA of the wild type protein... change one or more amino acids... run the screen... get a good feel for what part of the small molecule is interacting with the part that you have changed”

Ian Quigley, Leash Bio · Latent Space: The AI Engineer Podcast · Lab-in-the-Loop at Compute Speed - Ian Quigley, Leash Bio

Play from 1:07:37
1:07:37

Audio streams from the publisher’s own feed. Verbatim does not host or copy it.

What was described

engineered mutations in the binding pocket of proteins, then re-screened large DNA-encoded libraries to map which amino acids drive binding behavior

Said nearby on the same subject

“We're launching a multivitamin called Vita Hustle. After that, we'll be doing amino acids. We'll then be doing organic protein.”
♫
Said on Tony Robbins Podcast Daily
Why it worked Share this moment
“We can actually interpret where Hermes thinks the binding pocket is... it was looking at short sequences away from the functional part”
IQ
Ian Quigley Leash Bio
Latent Space: The AI Engineer Podcast ·
“We buy a known binder, run the screen again… all the chemicals that normally go in the pocket will be displaced… then we mutate the pocket and see those series drop out.”
IQ
Ian Quigley
Latent Space: The AI Engineer Podcast ·
How they work Share this moment
“You can have an AI generate XAML page on the fly and then run it, use binding to load data, and maybe add some custom controls from the business logic of your app”
♫
Said on .NET Rocks!
Automation Share this moment

Moments like this, every Monday

The strongest new moments on your topics, in the speakers' own words. Free for three topics.

No card. No password. One-click unsubscribe.

Track a competitor?

Pro watches up to 25 names or phrases and emails you the morning after they are said.

See Pro, $29 a month

Verbatim quotes a short extract and links to the episode; the episode belongs to its publisher. Remove a show.