“We could use synthetic biology… to edit the genome of these black-footed ferrets and make them resistant to plague.”

Dr. Beth Shapiro · Huberman Lab · Bringing Extinct Species Back to Life | Dr. Beth Shapiro

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What was described

Use synthetic biology to edit the genome of black-footed ferrets to make them resistant to plague

Said nearby on the same subject

“And every year they can release about 500 black-footed ferrets into the wild.”
♫
Said on Huberman Lab
How they work 500 per year Share this moment
“We have 20 edits that we picked, and we sequenced genomes from fossil dire wolves… we engineered those changes into a gray wolf genome to recreate the dire wolf”
DS
Dr. Beth Shapiro
Huberman Lab ·
Why it worked 20 edits Share this moment
“You say, okay, of all the chemicals that I could make given my geometry, I don't want to make that many… you basically set up and generate a bunch of synthetic libraries and then you score them on this optimization function”
IQ
Ian Quigley Leash Bio
Latent Space: The AI Engineer Podcast ·
How they work Share this moment
“By selecting for the marker that's associated with the disease resistance gene, you can automatically eliminate 50% of them.”
DR
Dr. Brian Rossenegel
Podcasts - RealAgriculture ·
Why it worked 50% of lines eliminated Share this moment

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